Alternariol and Alternariol Methyl Ether

alternaria toxin

Alternaria species produces many different potent mycotoxins from which the tenuazonic acid, alternariol and altenariol methyl ether are the most common.  Alternariol and alternariol methyl ether toxins are commonly found in contaminated cereals and fruits such as tangerines, melons, melons, apples, gooseberries, olives, tomatoes, carrots and others.

Several of the Alternaria species are capable of producing these toxins and have been isolated from  Alternaria . tenuissima, A. brassicae, A. capsici-annui, A. citri, A. cucumerina, A. dauci, A. kikuchiana, A. longipes, A. porri, A. solani and A. tomato.

Alternariol and alternariol methyl ether are  carcinogenic?, cytotoxic?, fetotoxic?, mutagenic?, teratogenic? , genotoxic? , cholinesterase inhibitors? and also exhibit antifungal? and phytotoxic? activity. Alternariol also been shown to possess DNA strand-breaking activity and inhibits the activity of topoisomerase IIα in mammalian cell models. Altenrariol and alternariol methyl ether  as contaminants of animal food can also impair fertility in farm animals.

alternaria toxins

Alternariol monomethyl ether produced by A. solani was found to be toxic to hamsters when applied intraperitoneally at 200 mg/kg bw, whereas no toxic effects were observed at a dose level of 50 or 100 mg/kg bw. Both alternariol and alternariol monomethyl ether, which are frequently found in combination, were found to be mutagenic .  

Research carried out in China on people believed to suffered form a kind of mycotoxins poisoning revealed a strong link between A. alternata contaminated cereal grains and the high occurrence of oesophageal cancer. It is believed that long term exposure to low levels of this mycotoxin could be linked to the development of oesophageal cancer in exposed individuals.

Alternaria mycotoxins

Alternaria species produce more than 70 phytotoxins, but a small proportion of them have been chemically characterised and reported to act as mycotoxins to humans and animals. The most well know Alternaria toxins are: